Wilhelm was one the most significant members of his family. He came into politics very soon, taking over the custody of the family estates at 16 years old. He chose the Český Krumlov castle as his residential seat and he ordered it renovated into a chateau in Renaissance style. He also took care of the economic development of his estates. He had a very good regent,
Jakub Krčín of Jelčany and Sedlčany. Wilhem was a tolerant Catholic, even though he established a Jesuit college in Český Krumlov at
Horní No. 154 street. As the highest royal officer in Prague, he served the emperor Maxmilián II. and the emperor
Rudolf II. von Habsburg as a diplomat. He was married four times but did not have any children from any of his marriages, and for this reason his brother
Peter Wok von Rosenberg took over the custody of his estates when Wilhelm died. See also
Renaissance magnate Wilhelm von Rosenberg.